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Invasive aspergillosis involving multiple paranasal sinuses--a case report.

S Agarwal1, A Kanga, V Sharma

  • 1Department of Microbiology, Indira Gandhi Medical College, Shimla, Himachal Pradesh - 171 001, India.

Indian Journal of Medical Microbiology
|August 16, 2005
PubMed
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This case report details invasive fungal sinusitis caused by Aspergillus fumigatus in an immunocompetent patient. Surgical removal and antifungal medication successfully treated the paranasal sinus aspergillosis.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Otolaryngology

Background:

  • Invasive paranasal sinus aspergillosis (IPSA) is a rare fungal infection.
  • It typically affects immunocompromised individuals but can occur in immunocompetent hosts.
  • Early diagnosis and treatment are crucial to prevent complications.

Observation:

  • A young, immunocompetent woman presented with bilateral nasal obstruction.
  • Nasal polyps were identified, raising suspicion for a fungal etiology.
  • Radiological and histopathological examinations were performed.

Findings:

  • Diagnosis of invasive Aspergillus fumigatus infection was confirmed.
  • Microscopic examination revealed characteristic acute angle branching septate hyphae.

Related Experiment Videos

  • Fungal culture yielded Aspergillus fumigatus.
  • Implications:

    • This case highlights IPSA as a differential diagnosis in immunocompetent patients with sinonasal symptoms.
    • Aggressive surgical debridement combined with appropriate antifungal therapy (itraconazole) led to a favorable outcome.
    • Prompt diagnosis and management are essential for successful treatment of invasive fungal sinusitis.