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Related Experiment Videos

Cerebral infarction in IgG multiple myeloma with hyperviscosity.

Man-Seok Park1, Byeong-Chae Kim, In-Kyu Kim

  • 1Deptment of Neurology, Chonnam National University Medical School, Korea.

Journal of Korean Medical Science
|August 16, 2005
PubMed
Summary

Multiple myeloma with hyperviscosity can cause rare neurological complications like cerebral infarction. This case highlights hyperviscosity-induced stroke as an initial symptom of IgG multiple myeloma.

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Area of Science:

  • Hematology
  • Neurology
  • Oncology

Background:

  • Multiple myeloma, a plasma cell malignancy, can present with hyperviscosity syndrome.
  • Hyperviscosity is characterized by elevated serum viscosity, leading to diverse clinical symptoms.
  • Neurological deficits, including cerebral infarction, are uncommon but serious manifestations.

Observation:

  • A 68-year-old woman with IgG multiple myeloma presented with acute cerebral infarction.
  • Clinical symptoms included left leg hypesthesia and monoplegia, confirmed as stroke in the right anterior cerebral artery territory via MRI/MRA.
  • Diagnostic workup revealed IgG multiple myeloma with hyperviscosity, indicated by elevated ESR and abnormal protein electrophoresis.

Findings:

  • This case represents an initial manifestation of IgG multiple myeloma.

Related Experiment Videos

  • Hyperviscosity was identified as the direct cause of the cerebral infarction.
  • The patient's neurological deficits improved with chemotherapy.

    • Implications:

    • Highlights the importance of considering hyperviscosity in multiple myeloma patients with neurological symptoms.
    • Suggests prompt diagnosis and treatment of hyperviscosity are crucial for managing neurological complications.
    • Underscores the need for further research into the mechanisms linking myeloma, hyperviscosity, and stroke.