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Inflammatory cells and oxygen radicals.

Makoto Nagata1

  • 1Department of Respiratory Medicine, Saitama Medical School, 38 Morohongou, Moroyama-cho, Iruma-gun, Saitama 350-0495, Japan. favre4mn@saitama-med.ac.jp

Current Drug Targets. Inflammation and Allergy
|August 17, 2005
PubMed
Summary

Inflammatory cells generate reactive oxygen species (ROS), contributing to diseases like asthma. Eosinophils in the lungs produce more ROS than those in circulation, potentially worsening inflammation.

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Area of Science:

  • Immunology
  • Cell Biology
  • Pathophysiology

Background:

  • Inflammation involves various cells producing reactive oxygen species (ROS).
  • ROS contribute to disease development and inflammatory processes.
  • Allergic inflammation, specifically in asthma, involves ROS generation by lung cells.

Purpose of the Study:

  • To investigate the role of ROS in inflammatory cell interactions.
  • To understand the contribution of ROS to allergic inflammation and bronchial asthma.

Main Methods:

  • Analysis of inflammatory cells (eosinophils, neutrophils, macrophages) from sites of inflammation.
  • Measurement of superoxide anion generation by lung cells post-antigen challenge.
  • Comparison of ROS production in eosinophils from bronchoalveolar lavage (BAL) versus peripheral circulation.

Main Results:

  • Inflammatory cells generate ROS at sites of inflammation.
  • Lung cells from BAL produce superoxide anion at nanomolar concentrations after antigen challenge.
  • Eosinophils from BAL exhibit higher superoxide anion generation than peripheral eosinophils.
  • ROS, like hydrogen peroxide, upregulate beta2 integrin, promoting cell adhesion.
  • ROS can alter endothelial cell properties, increasing inflammatory and endothelial cell interactions.

Conclusions:

  • ROS produced by inflammatory cells contribute to tissue injury and inflammatory reactions.
  • Increased ROS in allergic inflammation, particularly by eosinophils, may exacerbate disease.
  • ROS-mediated cell adhesion and endothelial cell alterations can lead to inflammatory disease manifestations, such as bronchial asthma.

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