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Chronic urticaria and associated coeliac disease in children: a case-control study

L Caminiti1, G Passalacqua, G Magazzù

  • 1Department of Pediatrics, Allergy Unit, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|August 17, 2005
PubMed

Insights

Celiac disease (CD) is more common in children with chronic urticaria (CU). A gluten-free diet (GFD) can effectively treat chronic urticaria in these patients, suggesting CD may be a cause.

Area of Science:

  • Immunology
  • Gastroenterology
  • Dermatology

Background:

  • Celiac disease (CD) and chronic urticaria (CU) involve immune system dysregulation.
  • Limited research exists on the clinical association between CD and CU.

Purpose of the Study:

  • To investigate the prevalence of CD in children with CU.
  • To assess the clinical significance of CD in pediatric CU cases.

Main Methods:

  • A case-control study was conducted.
  • Children with severe chronic idiopathic urticaria unresponsive to antihistamines were enrolled.
  • Celiac disease was screened using serological markers and confirmed via intestinal biopsy.

Main Results:

  • Celiac disease was diagnosed in 5.0% of children with CU versus 0.67% in controls (p=0.0003).
  • In pediatric patients with both CU and CD, a gluten-free diet (GFD) led to rapid urticaria remission (5-10 weeks).
  • Serological markers for CD resolved over a longer period (5-9 months).

Conclusions:

  • Celiac disease is significantly more prevalent in children experiencing chronic urticaria.
  • A gluten-free diet demonstrates efficacy in achieving urticaria remission.
  • CD should be considered a potential underlying cause of chronic urticaria in affected children.
Abstract

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