Clinical course and outcome of uveitis in children

Ronit Friling1, Michal Kramer, Moshe Snir

  • 1Pediatric Ophthalmology Unit, Schneider Children's Medical Center of Israel, Petah Tikva, Israel. ronitf@post.tau.ac.il

Insights

Pediatric uveitis, a serious eye condition in children, can lead to complications but shows improved visual acuity with treatment. Intensive management offers a good visual prognosis, even in severe cases of childhood uveitis.

Area of Science:

  • Ophthalmology
  • Pediatrics
  • Rheumatology

Background:

  • Childhood uveitis is a significant cause of vision loss in children.
  • Understanding its clinical course and outcomes is crucial for effective management.

Purpose of the Study:

  • To evaluate the clinical course, complications, and visual outcomes of pediatric uveitis.
  • To assess the effectiveness of various treatment modalities.

Main Methods:

  • Retrospective analysis of 38 children with uveitis treated between 1986 and 2002.
  • Classified patients into idiopathic uveitis, Behcet disease, and juvenile rheumatoid arthritis groups.
  • Treatment included topical, periocular, or systemic steroids with or without immunosuppression.

Main Results:

  • Complications were observed in all groups, with higher severity in juvenile rheumatoid arthritis.
  • Statistically significant improvement in visual acuity was noted for idiopathic uveitis and Behcet disease.
  • Overall visual acuity improved from presentation to final examination.

Conclusions:

  • Intensive treatment approaches are recommended for childhood uveitis.
  • The visual prognosis for pediatric uveitis is generally good, even with severe disease.
  • Early and aggressive management can lead to favorable visual outcomes.
Abstract

Related Concept Videos

Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...