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Updated: Jul 15, 2026

Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
Published on: March 11, 2016
Calcific retinal embolism as an indicator of severe unrecognised cardiovascular disease
G Ramakrishna1, J F Malouf, B R Younge
1Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.
Insights
Calcific retinal embolism (CRE) can signal underlying severe heart valve disease, even in asymptomatic patients. Early detection through echocardiography is crucial for identifying this significant cardiovascular risk.
Area of Science:
- Ophthalmology
- Cardiology
- Vascular Medicine
Background:
- Calcific retinal embolism (CRE) is a rare condition.
- The association between CRE and cardiac valve stenosis is not well-established.
Purpose of the Study:
- To describe the association between calcific retinal embolism (CRE) and cardiac valve stenosis.
- To investigate the prevalence of cardiac valve stenosis in patients with CRE.
Main Methods:
- Retrospective chart review of patients diagnosed with CRE.
- Analysis of echocardiography data from 24 patients with CRE.
Main Results:
- Nine patients (38%) exhibited calcific valve stenosis.
- Five patients had hemodynamically severe valve stenosis (four aortic, one mitral).
- Four patients with severe stenosis were asymptomatic.
Conclusions:
- CRE may be an early indicator of significant, potentially asymptomatic, cardiovascular disease.
- Severe calcific valve stenosis is a notable underlying condition in patients with CRE.
Objective:
To describe the association between calcific retinal embolism (CRE) and cardiac valve stenosis.
Design And Setting:
Retrospective chart review of patients with clinical criteria for CRE.
Patients:
24 patients with CRE who underwent two dimensional echocardiography between 1976 and 1998.
Results:
Nine patients (38%) had calcific valve stenosis, which was haemodynamically severe in five patients (four aortic and one mitral), four of whom had no cardiac symptoms. Six patients underwent surgical intervention (aortic valve replacement in three patients, mitral and aortic valve replacement in one patient, removal of calcific cardiac pseudotumour in one patient, and carotid endarterectomy in one patient).
Conclusions:
CRE may be the presenting feature of otherwise asymptomatic, clinically important underlying cardiovascular disease and, in particular, haemodynamically severe calcific valve stenosis.
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