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Related Experiment Videos

Use of a probiotic to decrease enteric hyperoxaluria.

John C Lieske1, David S Goldfarb, Claudio De Simone

  • 1Division of Nephrology and Hypertension, Mayo Clinic, Mayo Hyperoxaluria Center, and Mayo Complementary and Integrative Medicine Program, Rochester, Minnesota 55905, USA. Lieske.John@mayo.edu

Kidney International
|August 18, 2005
PubMed
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A lactic acid bacteria mixture (Oxadrop) reduced urinary oxalate excretion in patients with fat malabsorption and kidney stones. This intervention shows potential for lowering stone formation risk by decreasing calcium oxalate supersaturation.

Area of Science:

  • Gastroenterology and Nephrology
  • Microbiome Research
  • Urolithiasis

Background:

  • Patients with inflammatory bowel disease face a significantly higher risk of nephrolithiasis.
  • Enteric hyperoxaluria is a primary risk factor for kidney stones in patients with fat malabsorption.
  • Intestinal microflora may play a role in limiting dietary oxalate absorption.

Purpose of the Study:

  • To investigate the effect of a lactic acid bacteria mixture on urinary oxalate excretion in patients with chronic fat malabsorption and hyperoxaluria.
  • To assess the impact of manipulating gastrointestinal flora on calcium oxalate supersaturation.

Main Methods:

  • Ten patients with chronic fat malabsorption, calcium oxalate stones, and hyperoxaluria underwent a 3-month trial with increasing doses of a lactic acid bacteria mixture (Oxadrop).

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  • A washout month followed the treatment period.
  • Twenty-four-hour urine collections were performed at baseline and monthly to measure urinary oxalate and other parameters.

    • Main Results:

    • Mean urinary oxalate excretion decreased by 19% after 1 month and 24% after 2 months of Oxadrop treatment.
    • Calcium oxalate supersaturation was reduced during Oxadrop treatment, primarily due to decreased oxalate excretion.
    • While urinary oxalate levels increased slightly in the third month, they fell again during the washout period.

    Conclusions:

    • Modulating gastrointestinal flora can effectively reduce urinary oxalate excretion and lower urinary supersaturation.
    • These findings suggest a potential benefit of this approach in reducing kidney stone formation rates.
    • Further research is necessary to determine the optimal dosing strategy for this intervention.