Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Direct stenting with sirolimus-eluting stents.

Michael Schlüter1, Joachim Schofer

  • 1Hamburg University Cardiovascular Center, Hamburg, Germany. schlueter@center-for-cardiology.de

The American Heart Hospital Journal
|August 18, 2005
PubMed
Summary

Direct stenting with sirolimus-eluting stents is safe and effective for suitable coronary lesions. However, conclusive evidence on its superiority over predilated stenting is currently lacking due to a shortage of randomized trials.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Method for Optical Quantification of Local Oxygen Limitations in Multiphase Bioreactors.

Biotechnology and bioengineering·2026
Same author

Leaflet Splitting to Prevent TAVR-Induced Coronary Obstruction in Stented vs Stentless Surgical Bioprosthetic Valves.

JACC. Cardiovascular interventions·2026
Same author

Supra-Annular Versus Intra-Annular Devices for Transcatheter Aortic Valve-in-Valve Replacement: The PANDORA International Registry.

Journal of the American Heart Association·2026
Same author

Impact of Proportionality of Secondary Tricuspid Regurgitation on Outcomes After Tricuspid Transcatheter Edge-to-Edge Repair.

Circulation. Cardiovascular interventions·2026
Same author

Management and Outcome of Failed Transcatheter Tricuspid Edge-to-Edge Repair: Insights From the FATE International Registry.

JACC. Cardiovascular interventions·2026
Same author

Advanced Glycerol Oxidation to Formic Acid in a Multiphasic Jet Loop Reactor Using Polyoxometalate Catalysts.

ACS sustainable chemistry & engineering·2026

Area of Science:

  • Interventional Cardiology
  • Cardiovascular Devices
  • Medical Technology

Background:

  • Sirolimus-eluting stents (SES) are widely used for coronary artery disease.
  • Lesion predilation is the standard implantation strategy in clinical trials.
  • Direct stenting without predilation has been explored in specific trials and registries.

Purpose of the Study:

  • To evaluate the safety and efficacy of direct sirolimus-eluting stent implantation.
  • To compare direct stenting with conventional predilated stenting.
  • To assess the current evidence regarding implantation strategies for SES.

Main Methods:

  • Review of randomized controlled trials and post-marketing surveillance registries involving SES.
  • Analysis of implantation strategies: direct stenting versus lesion predilation.

Related Experiment Videos

  • Assessment of patient, lesion, and procedural characteristics in comparative studies.

    • Main Results:

    • Direct SES implantation appears safe and effective for suitable coronary lesions.
    • Comparisons with predilated stenting were confounded by patient and lesion characteristics.
    • No randomized trials directly comparing implantation strategies are available.

    Conclusions:

    • Direct sirolimus-eluting stenting is a viable option for select coronary lesions.
    • Current evidence does not conclusively prove the superiority of direct over predilated stenting.
    • Further randomized trials are needed to establish the optimal implantation strategy.