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A case-control study to examine HLA haplotype associations in patients with posttreatment chronic Lyme disease

Mark S Klempner1, Gary H Wormser, Karen Wade

  • 1Boston University School of Medicine and Boston Medical Center, Massachusetts 02118, USA. klempner@bu.edu

The Journal of Infectious Diseases
|August 19, 2005
PubMed

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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...