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[Elementary evaluation of small intestinal submucosa and polypropylene mesh used for repairing abdominal wall defect
Xihai Zhang1, Jingcong Luo, Zhiming Yang
1Division of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
Objective:
To compare the effect of small intestinal submucosa (SIS) and polypropylene mesh (PPM) on repairing abdominal wall defects in rats, and to probe into the feasibility of using SIS to repair the abdominal wall defects.
Methods:
100 SD rats (50 males and 50 females)were randomly divided into 2 groups (n = 50). Their weight ranged from 200 to 250 g. Full thickness abdominal wall defects (2 cmX 2 cm) were created by surgery and were repaired with SIS and PPM respectively. At different postoperative time (1st, 2nd, 4th, 8th and 12th week), animals were sacrificed to make histological observation. The tensile strength and the development of adhesions were measured and observed.
Results:
95 animals survived and were healthy after surgery. No inflammatory response and obvious immunoreaction were observed in both groups. One week after operation, the tensile strength of abdominal wall in SIS group (204.30+/-5.13 mmHg) was lower than that in PPM group(240.0+/-10.0 mmHg) at 1st week (P<0.05), and there were no difference at 4th, 8th, 12th week. Adhesions were more marked in PPM group than that in SIS group (P<0.05).
Conclusion:
Both SIS and PPM are histologically compatible when used in rats and can maintain sufficient tensile strength. SIS is superior to PPM in regards to tissue compatibility and adhesion formation.
