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[Maternal diabetes and congenital malformations]

Malene Nygaard Johansen1, Ester Garne

  • 1Syddansk Universitet, Epidemiologi, og Kolding Sygehus, Børneafdelingen. malene.johansen@get2net.dk

Ugeskrift for Laeger
|August 20, 2005
PubMed

Maternal diabetes is a known risk factor for congenital malformations. Maternal hyperglycemia is a non-specific teratogen. The risk of congenital malformations, even with optimal metabolic control, is considerably elevated compared with non-diabetic pregnancies. The relationship between maternal hyperglycemia in early pregnancy and the risk of congenital malformations seems to be linear without any threshold level. To diminish the risk of congenital malformations, close preconceptional and first-trimester diabetic control and folic acid supplementation of 5 mg/day are recommended.

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