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Cyclosporin for inflammatory pseudotumour.
T Nishimaki1, H Matsuzaki, Y Sato
1Second Department of Internal Medicine, Fukushima Medical College, Japan.
Internal Medicine (Tokyo, Japan)
|March 1, 1992
Summary
Cyclosporin demonstrated significant effectiveness in treating a patient with liver inflammatory pseudotumor. This immunosuppressant rapidly resolved symptoms like fever and joint pain, and reduced liver lesions.
Area of Science:
- Immunology
- Hepatology
- Oncology
Background:
- A 30-year-old male presented with a history of recurrent high fever, polyarthralgia, and lymphadenopathy since 1981.
- Abdominal CT revealed multiple liver space-occupying lesions, with histopathology confirming inflammatory pseudotumor characterized by plasma cell and lymphocyte infiltration and collagen proliferation.
Observation:
- The patient developed diabetes mellitus in March 1990.
- Treatment with cyclosporin A and prednisolone was initiated in May 1990.
Findings:
- Rapid subsidence of high fever and polyarthralgia within days of cyclosporin A treatment.
- Normalization of leukocytosis (32,000/mm3) and C-reactive protein (17.7 mg/dl) within one month.
- Significant reduction in the size of liver lesions observed on CT scan one month post-treatment.
Implications:
- Cyclosporin A shows potential as an effective therapeutic agent for inflammatory pseudotumors of the liver.
- This case highlights the utility of immunosuppressive therapy in managing complex liver lesions.
- Further research into cyclosporin's role in treating similar conditions is warranted.