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Parallel changes in gene expression in aged human and mouse cortex.

Edward H Sharman1, Kaizhi G Sharman, Stephen C Bondy

  • 1Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, 19772 Jamboree, Irvine, CA 92697-1825, USA. esharman@uci.edu

Neuroscience Letters
|August 23, 2005
PubMed
Summary
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Aging significantly alters the expression of around 300 genes in the cerebral cortex of both humans and mice. This study highlights a strong correlation in age-related gene expression changes, validating mouse models for aging research.

Area of Science:

  • Neuroscience
  • Genetics
  • Aging Research

Background:

  • Gene expression profiling of the human and mouse cerebral cortex has been previously established, covering over 20,000 genes.
  • Senescence, or aging, is known to impact gene expression patterns in the brain.

Purpose of the Study:

  • To compare age-related changes in messenger RNA (mRNA) levels between human and mouse cerebral cortex.
  • To identify conserved genetic alterations associated with aging across species.
  • To validate the utility of mouse models for studying aging-related genetic events.

Main Methods:

  • Analysis of gene expression data from the cerebral cortex of aged and young individuals/mice.
  • Comparative analysis of mRNA expression levels for approximately 300 significantly altered genes.

Related Experiment Videos

  • Statistical correlation of age-dependent gene expression changes between species.

    • Main Results:

    • A significant number of genes (around 300) show altered expression in the cerebral cortex during senescence in both humans and mice.
    • A strong positive correlation was observed between human and mouse genomes regarding specific genes with marked age-related expression changes.
    • These findings indicate conserved molecular mechanisms of aging in the mammalian brain.

    Conclusions:

    • The expression of a core set of genes in the cerebral cortex is consistently altered during aging in both humans and mice.
    • The observed cross-species correlation validates the use of mouse models to investigate the genetic underpinnings of aging.
    • This research provides a foundation for further studies into age-related neurological decline and potential interventions.