Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human hippocampal theta activity during virtual navigation.

Arne D Ekstrom1, Jeremy B Caplan, Emily Ho

  • 1Division of Brain Mapping and Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, 90095, USA.

Hippocampus
|August 23, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incident hyponatremia among skilled nursing facility residents: association with enteral feeding tube use and chronic comorbidities.

BMC nephrology·2026
Same author

Modeling the journey as well as the destination: a control theory account of rotational navigation.

bioRxiv : the preprint server for biology·2026
Same author

Hernia recurrence postconcurrent hernia repair and metabolic and bariatric surgery versus ventral hernia repair alone.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery·2026
Same author

Retrieval-related Eye Movements Are Predictive of Memory Precision.

Journal of cognitive neuroscience·2026
Same author

Modulation of Microbiota-Derived Bile Acids Linked to Symptom Amelioration in Crohn's Disease: Insights From a Randomized Clinical Trial With Xanthohumol Supplementation.

Molecular nutrition & food research·2026
Same author

CLO26-123: Genomic Adjusted Radiation Dose (GARD) Predicts Optimal Radiation Dose for Overall Survival in Triple-Negative Breast Cancer.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same journal

Opioid-Associated Hippocampal Injury: Past, Present, and Future Directions.

Hippocampus·2026
Same journal

Neural and Navigational Features Influencing the Novelty Induced Benefits on Episodic Memory.

Hippocampus·2026
Same journal

Intrinsic Persistent Firing in CA1 Encodes Elapsed Time Across Behaviorally Relevant Scales.

Hippocampus·2026
Same journal

Boundary Vector Cells Encode a Future-Biased Spectrum of Positions in the Rat.

Hippocampus·2026
Same journal

Hippocampal NOP Receptor Activation Impairs Object Recognition Memory Acquisition.

Hippocampus·2026
Same journal

Effects of Corticotropin-Releasing Factor 1 Receptor Antagonism on In Vivo Dentate Gyrus Long-Term Potentiation in the TgF344-AD Rat Model of Alzheimer's Disease.

Hippocampus·2026
See all related articles

Movement-related theta oscillations exist in the human hippocampus. These brain waves increase during virtual navigation, suggesting a role in attention and sensorimotor integration.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Human Electrophysiology

Background:

  • Rodent studies show 4-8 Hz theta oscillations in the hippocampus increase during movement.
  • The presence and function of similar theta oscillations in the human hippocampus remain less understood.

Purpose of the Study:

  • To investigate the existence of 4-8 Hz theta oscillations in the human hippocampus.
  • To determine if these oscillations increase during virtual movement and searching tasks.
  • To explore the relationship between hippocampal and neocortical theta activity.

Main Methods:

  • Analysis of hippocampal and neocortical depth electrode recordings from six epilepsy patients.
  • Patients performed a virtual taxi-driver game involving searching and navigation.

Related Experiment Videos

  • Measured theta activity during different game phases (searching, delivery, movement).

    • Main Results:

    • Movement-related theta oscillations were observed in both the human hippocampus and neocortex.
    • Theta activity significantly increased during virtual movement across all game phases.
    • A significant correlation was found between hippocampal and neocortical theta activity.

    Conclusions:

    • Confirms the presence of movement-related theta oscillations in the human hippocampus.
    • Suggests that both cortical and hippocampal theta oscillations are involved in attention and sensorimotor integration.
    • Highlights the conserved role of theta oscillations in navigation and related cognitive functions across species.