Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New anti-inflammatory formulation containing Synurus deltoides extract.

Yong Hwan Choi1, Kun Ho Son, Hyeun Wook Chang

  • 1College of Pharmacy, Kangwon National University, Chunchon 200-701, Korea.

Archives of Pharmacal Research
|August 24, 2005
PubMed
Summary

A new anti-inflammatory formulation (SAG) containing Synurus deltoides extract demonstrated significant efficacy in reducing acute and chronic inflammation in animal models. Its action mechanism involves inhibiting prostaglandin production via cyclooxygenase (COX)-1 and COX-2 pathways.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lab-on-paper for molecular testing with USB-powered isothermal amplification and fluidic control.

Mikrochimica acta·2025
Same author

Advanced Practice Registered Nurse Full Practice Authority, Provider Supply, and Health Outcomes: A Border Analysis.

Policy, politics & nursing practice·2023
Same author

The Long Search for Pharmacologically Useful Anti-Inflammatory Flavonoids and Their Action Mechanisms: Past, Present, and Future.

Biomolecules & therapeutics·2022
Same author

Improvement of testosterone deficiency by fermented <i>Momordica charantia</i> extracts in aging male rats.

Food science and biotechnology·2021
Same author

Interruption of <i>Helicobacter pylori</i>-Induced NLRP3 Inflammasome Activation by Chalcone Derivatives.

Biomolecules & therapeutics·2021
Same author

Flavonoids from Scutellaria baicalensis inhibit senescence-associated secretory phenotype production by interrupting IκBζ/C/EBPβ pathway: Inhibition of age-related inflammation.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2020

Area of Science:

  • Pharmacology
  • Natural Product Chemistry
  • Inflammation Research

Background:

  • Synurus deltoides exhibits known anti-inflammatory and analgesic properties.
  • Developing novel anti-inflammatory agents from natural sources is a key research area.
  • Chronic inflammation requires effective and safe therapeutic interventions.

Purpose of the Study:

  • To evaluate the in vivo anti-inflammatory activity of a new formulation (SAG) containing S. deltoides extract.
  • To investigate the plausible mechanism of action for SAG's anti-inflammatory effects.
  • To assess SAG's efficacy in both acute and chronic inflammation animal models.

Main Methods:

  • Formulation of SAG with S. deltoides extract, Angelica gigas extract, and glucosamine sulfate.

Related Experiment Videos

  • Evaluation of anti-inflammatory activity using arachidonic acid (AA) and 12-O-tetradecanoyl 13-acetate (TPA)-induced ear edema models in mice.
  • Investigation of prostaglandin E2 (PGE2) production and cyclooxygenase (COX)-1/COX-2 activity in vitro and in vivo.

    • Main Results:

    • SAG dose-dependently inhibited AA- and TPA-induced ear edema in acute inflammation models.
    • SAG demonstrated significant inhibition of chronic inflammation and reduced PGE2 production in vivo.
    • In vitro studies showed SAG and S. deltoides extract inhibited COX-1 and COX-2 activity.

    Conclusions:

    • SAG possesses significant anti-inflammatory activity against acute and chronic inflammation models.
    • The anti-inflammatory effect is attributed to the inhibition of prostaglandin production via COX-1/COX-2 pathways.
    • SAG shows potential as a neutraceutical for inflammatory disorders, with S. deltoides extract likely contributing to COX inhibition.