Related Experiment Video
Updated: Aug 16, 2026

12:50
Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
Luteolin inhibits endothelin-1 secretion in cultured endothelial cells
Takaharu Kozakai1, Akiko Yamanaka, Toshio Ichiba
1Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan. tkoza@syd.odn.ne.jp
Bioscience, Biotechnology, and Biochemistry
|August 24, 2005
Abstract:
We discovered that luteolin, a typical flavonoid contained in various kinds of plants, inhibits the secretion and gene expression of endothelin-1 (ET-1), a potent vasoconstrictor regulating blood pressure, in porcine aortic endothelial cells. Its ED50 was about 10 microM. In addition, the inhibition of ET-1 by a glycoside compound of luteolin (luteolin-6-C-glucoside) was weak.
