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Related Experiment Videos

Screening for colorectal cancer.

Matti Hakama1, Geir Hoff, Ole Kronborg

  • 1Finnish Cancer Registry Institute for Statistical and Epidemiological Cancer research, Helsinki, Finland. matti.hakama@uta.fi

Acta Oncologica (Stockholm, Sweden)
|August 25, 2005
PubMed
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Colorectal cancer (CRC) screening using the fecal occult blood test (FOBT) shows significant mortality reduction. Further research is needed on public health service effectiveness and costs.

Area of Science:

  • Oncology
  • Public Health
  • Gastroenterology

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer death in Nordic countries.
  • Early detection and precursor removal (adenomas) can cure or prevent CRC.
  • CRC screening meets many criteria for effective population-based health interventions.

Purpose of the Study:

  • To evaluate the efficacy and effectiveness of fecal occult blood test (FOBT) screening for colorectal cancer.
  • To assess the impact of CRC screening on mortality rates.
  • To examine the feasibility and cost-effectiveness of population-based CRC screening programs.

Main Methods:

  • Review of randomized controlled trials (RCTs) using Hemoccult-II for CRC screening.
  • Analysis of long-term follow-up data on CRC mortality reduction.

Related Experiment Videos

  • Examination of public health policies and feasibility studies in Nordic countries (Denmark, Finland, Norway, Sweden).

    • Main Results:

    • Biennial FOBT screening (Hemoccult-II) demonstrated a 15-18% CRC mortality reduction in targeted populations.
    • Attended screening showed an estimated 23% mortality reduction.
    • Evidence supports FOBT efficacy, but effectiveness in public health services and cost-benefit analyses require further investigation.

    Conclusions:

    • Fecal occult blood test screening is effective in reducing colorectal cancer mortality.
    • Population-based screening feasibility studies are underway in some Nordic countries.
    • More research is needed on the real-world effectiveness, harms, and costs of public health CRC screening programs.