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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Arterial compliance in elderly men with chronic kidney disease

Sri G Yarlagadda1, Ambreen Hussain, Dawn M Bravata

  • 1Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, USA.

American Journal of Nephrology
|August 25, 2005
PubMed

Insights

Older men with chronic kidney disease (CKD) have reduced arterial compliance. However, the study found no link between glomerular filtration rate (GFR) and arterial stiffness in CKD patients.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Geriatrics

Background:

  • Chronic kidney disease (CKD) is linked to reduced arterial compliance (AC).
  • The relationship between impaired arterial function and declining glomerular filtration rate (GFR) in CKD remains unclear.

Purpose of the Study:

  • To investigate the association between GFR and AC in male patients with CKD.
  • To determine if GFR or CKD stage correlates with the degree of arterial stiffness.

Main Methods:

  • Cross-sectional study of 91 men aged 60+ years with GFR ranging from 15-89 ml/min.
  • Arterial compliance measured as brachial artery distensibility (BAD) using an oscillometric device.

Main Results:

  • No significant correlation was found between GFR and BAD (r = 0.08, p = 0.44).
  • All CKD stage groups exhibited decreased BAD compared to reference values, with no significant differences among stages.
  • BAD was significantly correlated with age, number of antihypertensive drugs, and serum hemoglobin, but only age and antihypertensive drug number remained significant in multiple regression analysis.

Conclusions:

  • Older men with CKD exhibit impaired arterial function.
  • GFR and CKD stage do not appear to influence the extent of brachial artery distensibility reduction in this cohort.
Abstract

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