[Effects of metformin on endocrine parameters and reproductive function in women with polycystic ovary syndrome]

The effect of metformin has been studied among 42 patients of reproductive age with polycystic ovary syndrome. Therapy for 6-months was associated with regular menstrual cycle in 54.3% women, (ovulation was observed in 28.6%). After therapy 19.1% patients became pregnant. Serum levels LH fell from 16.3+/-1.45 to 8.9+/-0.82 IU/l, T from 3.3+/-0.17 to 2.0+/-0.17 nmol/l, (p<0.01). We noted increase of GH from 2.7+/-0.98 to 9.0+/-1.91 nmol/l and SHBG from 36.4+/-2.6 to 58.2+/-4.11 nmol/l, (p<0.01). After therapy we observed decrease of insulin responses during oral glucose tolerance test, (p<0.05).