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Ninhydrin sweat test in leprosy.

N Markendeya¹, C R Srinivas

¹Department of Dermatology, PSG Hospitals, Peelamedu, Coimbatore 641 004, India.

Indian Journal of Leprosy

|August 27, 2005

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A simple ninhydrin test effectively detects and grades sweat loss in leprosy patients, aiding diagnosis. This non-invasive method also helps differentiate Hansen's disease from other causes of hypopigmented lesions.

Area of Science:

Dermatology
Neurology
Clinical Diagnostics

Background:

Leprosy (Hansen's disease) characteristically causes loss of sensation.
Autonomic dysfunction in leprosy leads to impaired sweating in affected areas.
Accurate assessment of sweat function is crucial for leprosy diagnosis and management.

Purpose of the Study:

To evaluate a simple, non-invasive, and rapid method for detecting and grading sweat function loss in leprosy.
To assess the utility of the ninhydrin test in differentiating leprosy-related sweating abnormalities from other conditions causing hypopigmented lesions.

Main Methods:

A 1% ninhydrin in acetone solution was used for a topical sweat test.
The test was applied to 84 patients with various types of leprosy.

Related Experiment Videos

Sweating response was assessed to detect and grade autonomic dysfunction.

Main Results:

The ninhydrin test successfully detected and graded sweat function loss in 84 leprosy cases.
Normal sweating was observed in 16 patients with hypopigmented lesions unrelated to Hansen's disease.
The method proved effective in identifying sweat function abnormalities specific to leprosy.

Conclusions:

The ninhydrin test is a valuable, simple, and rapid tool for assessing sweat function in leprosy.
This diagnostic method aids in the clinical evaluation and management of Hansen's disease.
The test can help distinguish leprosy-induced anhidrosis from other causes of skin changes.