Related Experiment Video
Updated: Apr 1, 2026
03:10
Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
Published on: November 1, 2024
3.9K
Expert Consensus on the Rational Approach to Isotretinoin Usage for Effective Management of Acne: ERAISE ACNE
Sanjiv Kandhari1, Jayakar Thomas2, Niti Khunger3
1Department of Dermatology, Dr. Kandhari's Skin and Dental Clinic, New Delhi, India. skandhari21@gmail.com.
Dermatology and Therapy
|March 31, 2026
Summary
Oral isotretinoin is a gold standard for severe acne, with expert consensus supporting its early use for various acne types and patient groups. Dosing and monitoring recommendations aim to optimize treatment and improve quality of life.
Area of Science:
- Dermatology
- Pharmacology
- Clinical Practice Guidelines
Background:
- Oral isotretinoin is the primary treatment for severe acne, but its application varies globally.
- Clinical practice guidelines are needed to standardize dosing, monitoring, and adjunctive therapies for isotretinoin.
Purpose of the Study:
- To develop practical, expert-backed recommendations for oral isotretinoin use in acne management.
- To create a consensus-driven algorithm for isotretinoin application in Indian clinical settings.
Main Methods:
- Modified Delphi process involving 20 dermatology experts.
- Comprehensive literature review from 2000 to 2024.
- Development of the ERAISE ACNE algorithm.
Main Results:
- High consensus supported first-line isotretinoin for severe acne, acne with scarring/distress, and relapsing moderate acne in adults and adolescents.
- Early initiation and quality-of-life improvement were strongly agreed upon.
- Conventional dosing (0.5-1 mg/kg/day) favored for severe acne; low-dose (0.1-0.5 mg/kg/day) for moderate/persistent acne.
- Consensus acknowledged adverse effects, teratogenicity, and advised laboratory monitoring.
- Low consensus existed regarding cumulative dosing, monitoring frequency, and pre-pregnancy washout periods.
Conclusions:
- The ERAISE ACNE algorithm provides a practical framework for rational isotretinoin use, emphasizing early initiation, tailored dosing, and safety.
- Recommendations are applicable to clinical settings with similar demographic and healthcare challenges.
- Further consensus is needed on specific aspects like cumulative dosing and monitoring frequency.
Related Concept Videos
01:27Acne Infection
48
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
48
01:24Rational Dosage Regimen: Maintenance Dose and Loading Dose
5.9K
A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
5.9K
01:30Asthma-IV: Diagnostic and Management
3.3K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.3K
01:24Rational Emotive Behavior Therapy
658
Cognitive-behavioral therapies (CBTs) are grounded in the belief that our thoughts profoundly influence our emotions and actions. Advocates of CBT emphasize three core assumptions: first, that cognitions are identifiable and measurable; second, that they are central to psychological functioning; and third, that irrational or maladaptive beliefs can be replaced with rational and adaptive ones. This transformative approach to therapy has paved the way for specific models such as Albert...
658
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
2.0K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
2.0K
01:28Dosage Regimens: Designs and Approaches
467
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
467