Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Damage in trabecular bone at small strains.

Elise F Morgan1, Oscar C Yeh, Tony M Keaveny

  • 1Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, Berkeley, CA, 94720, USA. efmorgan@bu.edu

European Journal of Morphology
|August 27, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Can proton density-weighted MRI-based finite element models predict bone strength?

Bone·2026
Same author

Effects of romosozumab on bone strength around a pedicle screw as evaluated by biomechanical computed tomography-based virtual stress tests in postmenopausal women.

The spine journal : official journal of the North American Spine Society·2026
Same author

From imaging to insight: biomechanical CT for fracture risk prediction.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Femora from adults with type 1 or type 2 diabetes have lower bone strength and smaller hip geometry.

JBMR plus·2026
Same author

A Review on Osteoporosis.

JAMA·2025
Same author

Improved prediction of hip fracture using multi-faceted biomechanical computed tomography.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2025
Same journal

Undiagnosed fracture in a common foot variant: the biphalangeal little toe.

European journal of morphology·2006
Same journal

Permanently increased conductance of the murine uterine arcade after the first pregnancy.

European journal of morphology·2006
Same journal

Fractal dimension of the middle meningeal vessels: variation and evolution in Homo erectus, Neanderthals, and modern humans.

European journal of morphology·2006
Same journal

Tracking the changes in unloaded bone: Morphology and gene expression.

European journal of morphology·2006
Same journal

Influence of high-calorie (cafeteria) diets on the population of Paneth cells in the small intestine of the rat.

European journal of morphology·2006
Same journal

Mechanical anisotropy in cobra skin is related to body movement.

European journal of morphology·2006
See all related articles

Bone damage occurs at surprisingly low strains, even during normal daily activities. This micro-damage accumulation negatively impacts bone quality and fracture resistance.

Area of Science:

  • Biomechanics
  • Orthopedics
  • Materials Science

Background:

  • Bone damage affects quality and fracture risk.
  • Understanding damage thresholds in trabecular bone is crucial.
  • Habitual loading damage is not well understood.

Purpose of the Study:

  • Characterize damage accumulation in trabecular bone at small strains (0.20-0.45%).
  • Investigate damage initiation under habitual loading conditions.

Main Methods:

  • Continuum damage mechanics approach.
  • Tested human vertebral specimens (n=7) in compression.
  • Used multi-cycle load-unload protocol with incremental strain increases.
  • Quantified damage via changes in modulus and residual strain.

Related Experiment Videos

Main Results:

  • Damage (modulus change, residual strain) initiated at low strains (0.20-0.24%).
  • Strong correlations observed between modulus changes and residual strains (r=0.51-0.98).
  • Finite element analysis revealed tissue-level yielding at low apparent strains.

Conclusions:

  • Trabecular bone damage occurs at apparent strains below half the compressive yield strain.
  • Highly porous bone structure facilitates tissue yielding at low apparent strains.
  • Local failure initiation has detectable negative effects on apparent bone properties.