Related Experiment Video
Updated: Aug 16, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Alkamides from the leaves of Zanthoxylum syncarpum
Samir A Ross1, Mounirah A Al-Azeib, Kesanapalli S Krishnaveni
1National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677-1848, USA. sross@olemiss.edu
Abstract:
Three alkamides (1-3) were isolated from the leaves of Zanthoxylum syncarpum. The structures of the new compounds 1 and 2 were established by spectroscopic data and chemical conversion, and by the X-ray crystallography of 1. Compound 3, the racemic form of the known compound syncarpamide, showed moderate antiplasmodial activity, with IC50 values of 4.2 and 6.1 microM against Plasmodium falciparum D6 clone and W2 clone, respectively.
Related Concept Videos
Adaptations that Reduce Water Loss
Carboxylic Acids to Methylesters: Alkylation using Diazomethane
Preparation of 1° Amines: Azide Synthesis
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
Amines to Amides: Acylation of Amines
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary amide...
C4 Pathway and CAM
C4 Pathway
The C4 pathway is used by plants such as...
Cholinergic Antagonists: Pharmacokinetics
