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Hepatic pseudocapillarization in aged mice.

Alessandra Warren1, Patrick Bertolino, Victoria C Cogger

  • 1Centre for Education and Research on Ageing, University of Sydney, Concord RG Hospital, Sydney, NSW, Australia.

Experimental Gerontology
|August 30, 2005
PubMed
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Aging causes pseudocapillarization in mouse livers, characterized by thickened endothelium and reduced fenestrations. This confirms mice as a suitable model for studying liver aging and its associated diseases.

Area of Science:

  • Hepatology
  • Gerontology
  • Cell Biology

Background:

  • Age-related changes in the hepatic sinusoid, termed pseudocapillarization, are implicated in disease pathogenesis.
  • Previous studies documented pseudocapillarization in rats, humans, and baboons.

Purpose of the Study:

  • To investigate if pseudocapillarization occurs in the livers of old mice.
  • To evaluate the suitability of mice as a model for studying liver aging.

Main Methods:

  • Comparative analysis of young (3-4 months) and old (20-24 months) mouse livers.
  • Perfusion fixation, electron microscopy, and immunohistochemistry were employed.
  • Quantification of sinusoidal endothelial thickness and fenestration porosity.

Main Results:

Related Experiment Videos

  • Old mice exhibited significantly increased sinusoidal endothelial thickness (244+/-8 nm vs. 154+/-4 nm).
  • Fenestration porosity was reduced in old mice (2.2+/-0.2% vs. 4.1+/-0.3%).
  • Novel perisinusoidal fat-engorged stellate cells were observed in old mice.

Conclusions:

  • Pseudocapillarization is a widespread aging change in mouse livers, consistent with other species.
  • Mice serve as an appropriate animal model for investigating hepatic sinusoidal aging.