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Updated: Aug 16, 2026
A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Callus mineralization following distraction osteogenesis of the mandible monitored by scanning acoustic microscopy
Nicolai Adolphs1, Christoph Kunz, Pawel Pyk
1AO-Research Institute, Davos-Platz, Switzerland. n_adolphs@hotmail.com
Background:
Scanning acoustic microscopy uses ultrasound to analyse histomorphology of tissues with microscopic resolution and delivers data about physical properties of the specimen.
Material And Methods:
Bony consolidation was monitored by scanning acoustic microscopy in 12 embedded specimens of dog mandibles after distraction osteogenesis. Increasing mineralization was detected by measurements of acoustic impedance (Z).
Results:
There was a strong correlation between acoustic impedance and time of consolidation. Measurements of the speed of sound (v) provided specific information about non-mineralized zones of the distracted area. Distribution of density in the distracted area could be reconstructed by using the measurements of acoustic impedance and speed of sound.
Conclusion:
The method seems suitable for studying bone remodelling qualitatively and quantitatively.
