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Stiffness index derived from digital volume pulse as a marker of target organ damage in untreated hypertension

Ju-Yi Chen1, Wei-Chuan Tsai, Chih-Chan Lin

  • 1Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Medical Center, Tainan, Taiwan.

Blood Pressure
|August 30, 2005
PubMed

Insights

The stiffness index derived from digital volume pulse (SIDVP) correlates with target organ damage in untreated hypertension. This simple index is independently associated with vascular diseases, aiding risk stratification.

Area of Science:

  • Cardiovascular physiology
  • Biomedical engineering
  • Hypertension research

Background:

  • Large artery stiffness is a key cardiovascular risk factor.
  • Digital Volume Pulse (DVP) analysis offers a non-invasive method to assess arterial properties.
  • The Stiffness Index derived from DVP (SIDVP) is a novel index of large artery stiffness.

Purpose of the Study:

  • To investigate the role and clinical significance of SIDVP in untreated hypertensive patients.
  • To evaluate the association of SIDVP with target organ damage and vascular diseases.

Main Methods:

  • 124 untreated hypertensive patients were enrolled.
  • Digital Volume Pulse (DVP) was measured using photoplethysmography.
  • SIDVP was calculated, alongside aortic stiffness indices (SI, DI), and correlated with clinical markers.

Main Results:

  • SIDVP showed significant correlations with blood urea nitrogen (BUN) and left ventricular mass index (LVMI).
  • Patients with vascular diseases exhibited higher SIDVP, BUN, and lower distensibility (DI).
  • Multivariate analysis identified SIDVP as the sole independent predictor of vascular disease presence (OR 1.39).

Conclusions:

  • SIDVP, SI, and DI are correlated with target organ damage in hypertension.
  • SIDVP is independently associated with vascular diseases in untreated hypertensive individuals.
  • SIDVP derived from DVP is a valuable tool for risk stratification in hypertension.
Abstract

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