Jove
Visualize
Contact Us

Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bcl-2 family immunohistochemistry.

Methods in molecular medicine·2011
Same author

Guidelines for the welfare and use of animals in cancer research.

British journal of cancer·2010
Same author

Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026.

British journal of cancer·2005
Same author

Antitumor activity of imidazothioxanthones in murine and human tumor models in vitro and in vivo.

Anticancer research·2004
Same author

Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development.

European journal of cancer (Oxford, England : 1990)·2004
Same author

Variation in RNA expression and genomic DNA content acquired during cell culture.

British journal of cancer·2004
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 19, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Small molecule anticancer drugs.

L R Kelland1

  • 1CRC Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, SM2 5NG, Surrey, United Kingdom. lloyd@icr.ac.uk

Idrugs : the Investigational Drugs Journal
|August 30, 2005
PubMed
Summary

New cancer drugs target specific molecules like farnesyl transferase and cyclin-dependent kinases (cdk). While some show promise, further research is needed to confirm target specificity and optimize therapies for better antitumor activity.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Intensive drug discovery efforts are underway to develop more selective cancer therapies.
  • Advances in molecular understanding of cancer reveal new potential drug targets.
  • Current challenges include confirming in vivo target specificity and managing dose-limiting toxicities.

Purpose of the Study:

  • To review emerging molecular targets and drug candidates in cancer therapy.
  • To highlight the progress and challenges of farnesyl transferase and cyclin-dependent kinase inhibitors.
  • To identify potential new cancer therapies in preclinical development.

Main Methods:

  • Review of ongoing clinical trials for novel cancer therapeutics.
  • Analysis of preclinical research on molecular targets such as telomerase, MDM2, and c-Raf.

More Related Videos

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

Related Experiment Videos

Last Updated: Jul 19, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

  • Assessment of drug efficacy and toxicity data from early-phase trials.

    • Main Results:

    • Farnesyl transferase inhibitors (R115777, L778123) entered Phase I with dose-limiting myelosuppression; R115777 showed antitumor activity.
    • A broad-spectrum cyclin-dependent kinase (cdk) inhibitor, flavopiridol, is entering Phase II trials.
    • Concerns exist regarding the in vivo target specificity of current broad-spectrum inhibitors.

    Conclusions:

    • Selective inhibitors targeting specific molecular pathways represent a promising direction in cancer drug discovery.
    • Further development of selective cyclin-dependent kinase inhibitors is ongoing.
    • Preclinical investigations into targets like telomerase, MDM2, and c-Raf may yield novel cancer therapies within five years.