Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progesterone-dependent immunomodulation.

J Szekeres-Bartho1, B Polgar, N Kozma

  • 1Department of Medical Microbiology and Immunology, Pecs University, Medical School, Pecs, Hungary.

Chemical Immunology and Allergy
|September 1, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical management and innovation in fracture non-union.

Expert opinion on biological therapy·2024
Same author

Cartilage decisively shapes the glenoid concavity and contributes significantly to shoulder stability.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2022
Same author

Helical plating - a novel technique to increase stiffness in defect fractures.

European cells & materials·2021
Same author

Inhibitory effects of Vitamin D on inflammation and IL-6 release. A further support for COVID-19 management?

European review for medical and pharmacological sciences·2020
Same author

Fecal expression of Escherichia coli lysine decarboxylase (LdcC) is downregulated in E-cadherin negative lobular breast carcinoma.

Physiology international·2020
Same author

Progestogens and immunology.

Best practice & research. Clinical obstetrics & gynaecology·2019

Progesterone-induced blocking factor (PIBF) is crucial for successful pregnancy. Lower PIBF levels predict pregnancy termination, while PIBF treatment can correct pregnancy loss in mice.

Area of Science:

  • Immunology
  • Reproductive Biology
  • Cell Biology

Background:

  • Progesterone exerts biological effects via the progesterone-induced blocking factor (PIBF), a 34-kDa protein.
  • PIBF is synthesized by lymphocytes during healthy pregnancy and modulates immune responses.
  • PIBF influences arachidonic acid release, NK activity, and cytokine balance.

Purpose of the Study:

  • To elucidate the biological functions and significance of PIBF in pregnancy.
  • To investigate the role of PIBF in pregnancy outcomes and potential therapeutic applications.

Main Methods:

  • Analysis of PIBF synthesis and cellular localization (centrosome association, secretion).
  • Investigation of PIBF's effects on intracellular signaling pathways (STAT6, STAT4, PKC).

Related Experiment Videos

  • Correlation of urinary PIBF concentrations with pregnancy outcomes in humans and resorption rates in mice.

    • Main Results:

    • PIBF induces STAT6 nuclear translocation and PKC phosphorylation while inhibiting STAT4 phosphorylation.
    • Urinary PIBF concentration correlates with pregnancy success; low levels predict premature termination.
    • In vivo studies showed RU 486 treatment increased resorption rates due to impaired PIBF production, which was reversed by PIBF administration.

    Conclusions:

    • PIBF plays a critical role in maintaining pregnancy by modulating immune responses and intracellular signaling.
    • PIBF levels serve as a predictive marker for pregnancy outcomes.
    • PIBF demonstrates therapeutic potential for preventing pregnancy loss associated with immune dysregulation or progesterone receptor blockade.