Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunological Memory01:23

Immunological Memory

15.1K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
15.1K
Antibody Structure01:10

Antibody Structure

65.4K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
65.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibitory effects of Vitamin D on inflammation and IL-6 release. A further support for COVID-19 management?

European review for medical and pharmacological sciences·2020
Same author

Operation, hormone therapy and recovery of the patients with severe forms of adenomyosis.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2018
Same author

Managing immunity in resistant cancer patients correlates to survival: results and discussion of a pilot study.

Hormone molecular biology and clinical investigation·2015
Same author

A pilot study to determine whether progestogen supplementation using dydrogesterone during the first trimester will reduce the incidence of gestational hypertension in primigravidae.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2014
Same author

Implementation of certified endometriosis centers: 5-year experience in German-speaking Europe.

Gynecologic and obstetric investigation·2013
Same author

Progesterone-induced blocking factor (PIBF) and trophoblast invasiveness.

Journal of reproductive immunology·2011
Same journal

A risk-based classification of late-onset fetal growth disorders according to intrapartum fetal compromise.

Best practice & research. Clinical obstetrics & gynaecology·2026
Same journal

The Cardiac-Fetal-Placental Unit: links between umbilical venous flow and maternal hemodynamics in fetal growth restriction.

Best practice & research. Clinical obstetrics & gynaecology·2026
Same journal

Psychosocial interventions for women who are pregnant following a previous reproductive loss: A scoping review.

Best practice & research. Clinical obstetrics & gynaecology·2026
Same journal

Controversies in fetal therapy.

Best practice & research. Clinical obstetrics & gynaecology·2026
Same journal

Alloimmunisation in pregnancy: current management and future perspectives.

Best practice & research. Clinical obstetrics & gynaecology·2026
Same journal

Consensus in prenatal management of Hemolytic disease of the fetus and newborn.

Best practice & research. Clinical obstetrics & gynaecology·2026
See all related articles

Related Experiment Video

Updated: Jan 21, 2026

Imaging the Human Immunological Synapse
09:37

Imaging the Human Immunological Synapse

Published on: December 26, 2019

15.4K

Progestogens and immunology.

J Szekeres-Bartho1, A E Schindler2

  • 1Department of Medical Biology, Medical School, Pecs, Hungary; MTA - PTE Human Reproduction Research Group, Hungary; János Szentágothai Research Centre, University of Pecs, Hungary; Endocrine Studies, Centre of Excellence, Hungary.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|July 27, 2019
PubMed
Summary
This summary is machine-generated.

Progesterone-induced blocking factor (PIBF) regulates the maternal immune response to pregnancy by modulating immune cells and cytokines. This immune regulation is crucial for successful embryo implantation and maintaining pregnancy.

Keywords:
CytokinesExtracellular vesiclesImplantationNK cellsProgesterone

More Related Videos

Facilitating the Analysis of Immunological Data with Visual Analytic Techniques
10:58

Facilitating the Analysis of Immunological Data with Visual Analytic Techniques

Published on: January 2, 2011

10.5K
Supported Planar Bilayers for the Formation of Study of Immunological Synapses and Kinapse
12:24

Supported Planar Bilayers for the Formation of Study of Immunological Synapses and Kinapse

Published on: September 15, 2008

13.1K

Related Experiment Videos

Last Updated: Jan 21, 2026

Imaging the Human Immunological Synapse
09:37

Imaging the Human Immunological Synapse

Published on: December 26, 2019

15.4K
Facilitating the Analysis of Immunological Data with Visual Analytic Techniques
10:58

Facilitating the Analysis of Immunological Data with Visual Analytic Techniques

Published on: January 2, 2011

10.5K
Supported Planar Bilayers for the Formation of Study of Immunological Synapses and Kinapse
12:24

Supported Planar Bilayers for the Formation of Study of Immunological Synapses and Kinapse

Published on: September 15, 2008

13.1K

Area of Science:

  • Immunology
  • Reproductive Biology
  • Molecular Biology

Background:

  • Maternal immune system recognizes paternal fetal antigens, activating lymphocytes.
  • Progesterone binding to lymphocyte progesterone receptors (PRs) induces progesterone-induced blocking factor (PIBF).

Purpose of the Study:

  • To elucidate the role of PIBF in maternal-fetal immune interactions.
  • To understand PIBF's mechanism in successful pregnancy.

Main Methods:

  • Analysis of PIBF isoforms and their functions.
  • Investigating PIBF's role in immune cell communication via extracellular vesicles.

Main Results:

  • PIBF, produced upon progesterone-PR interaction, exists in various isoforms.
  • PIBF regulates maternal immune response by promoting Th2 cytokines and inhibiting NK cell degranulation.
  • PIBF-containing extracellular vesicles mediate embryo-maternal immune communication.

Conclusions:

  • PIBF is essential for successful embryo implantation and pregnancy maintenance.
  • PIBF acts as a crucial mediator in the maternal immune response to pregnancy.