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Related Experiment Videos

Recursive partitioning for risk stratification in men undergoing repeat prostate biopsies.

Mark Garzotto1, Yon Park, Solange Mongoue-Tchokote

  • 1Urology Section, Portland Veterans Administration Medical Center, Portland, Oregon 97239, USA. garzotto@ohsu.edu

Cancer
|September 1, 2005
PubMed
Summary

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Men with negative initial prostate biopsies still face prostate cancer risks. Key factors like PSA doubling time and HGPIN help identify high-risk groups for repeat biopsies.

Area of Science:

  • Urology
  • Oncology
  • Medical Diagnostics

Background:

  • Repeat prostate biopsies are common in men with initially negative results.
  • Identifying risk factors for prostate carcinoma detection is crucial in this population.

Purpose of the Study:

  • To identify risk factors for prostate carcinoma detection in men undergoing repeat prostate biopsies.
  • To stratify patients into distinct risk groups based on identified factors.

Main Methods:

  • Retrospective review of medical records for men with at least one repeat biopsy.
  • Analysis of clinical data including PSA values, PSAD, HGPIN, and family history.
  • Utilized log-rank test, Cox regression, and recursive partitioning for risk factor identification and stratification.

Related Experiment Videos

Main Results:

  • Prostate carcinoma was detected in 28.9% of patients during follow-up.
  • Independent predictors of positive biopsy included PSADT, PSAD, referral indication, HGPIN, age, and family history.
  • Four distinct risk groups were identified with varying 2- and 5-year cancer detection rates.

Conclusions:

  • Independent risk factors for prostate carcinoma detection post-negative biopsy were identified.
  • Clinically meaningful patient risk groups were characterized.
  • Patients with high-risk features after an initial negative biopsy remain at significant risk for prostate cancer.