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[Experimental study on anti-inflammatory effects of mahuang decoction and its compositions]
Yonggang Liu1, Jiabo Luo, Feng He
1Key Laboratory of Pharmaceutical of Materia Medica, Nanfang Medical University, Guangzhou.
Objective:
To explore the regularity of recipe composition by observing anti-inflammatory effects of Mahuang Decoction (MHD) and its compositions.
Methods:
Neutrophil aggregation was induced by intraperitoneal injection of glycogen in rats. Intraperitoneal lavage fluid (PLF) was collected and neutrophils were removed. Neutrophils were stimulated by calciumionophore A23187 in vitro to produce leukotriene B4. The concentration of leukotriene B4 was measured by reversed-phase HPLC, anti-inflammatory effect was observed by the auricular edema with dimethylbenze.
Result:
MHD and its compositions could inhibit the auricular edema with dimethylbenze and leukotriene production from neutrophils in rats. Inhibitory effects of MHD compositions were different.
Conclusion:
MHD had significantly inhibitory effects on the auricular edema with dimethylbenze and leukotriene production from neutrophils in rats. The original formula (MHD) worked best. These result confirmed the rationality and scientific level of MHD.