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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Characterization of inclusion complexation between fenoxaprop-p-ethyl and cyclodextrin
Anping Zhang1, Weiping Liu, Lumei Wang
1Research Center of Green Chirality, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China.
Journal of Agricultural and Food Chemistry
|September 1, 2005
Summary
Randomly methylated beta-cyclodextrin (RAMEB) significantly enhances the solubility and dissolution of fenoxaprop-p-ethyl (FE). This suggests RAMEB as a promising additive for improved FE delivery and environmental applications.
Area of Science:
- Materials Science
- Agricultural Chemistry
- Physical Chemistry
Background:
- Cyclodextrins (CDs) are starch-derived compounds forming inclusion complexes with organic molecules.
- Fenoxaprop-p-ethyl (FE) is an herbicide requiring efficient delivery systems.
- Developing advanced formulations can improve herbicide efficacy and environmental impact.
Purpose of the Study:
- To investigate the complexation of cyclodextrins with fenoxaprop-p-ethyl (FE).
- To evaluate the potential of cyclodextrins as formulation additives for FE.
- To assess the impact on FE solubility, dissolution, and environmental approaches.
Main Methods:
- Tested beta-cyclodextrin (beta-CD), randomly methylated beta-CD (RAMEB), and 2-hydroxypropyl beta-CD (HP-beta-CD).
- Assessed FE solubility and dissolution rates in the presence of CDs.
- Utilized differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD) to confirm complexation.
Main Results:
- All tested CDs enhanced FE solubility through inclusion complex formation.
- RAMEB showed over six times greater effectiveness in solubility enhancement compared to beta-CD and HP-beta-CD.
- Complexation was confirmed by weakened melting peaks (DSC), FTIR bands, and XRD patterns.
- FE-CD complexes exhibited higher FE concentrations upon dissolution than FE alone.
- The FE-RAMEB complex demonstrated significantly faster dissolution rates.
Conclusions:
- RAMEB is a superior complexation agent for FE, improving both solubility and dissolution rate.
- RAMEB holds potential for enhancing FE delivery systems.
- RAMEB could aid in mobilizing FE in soil for bioremediation purposes.
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