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Updated: Aug 16, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Classic Kaposi's sarcoma in Sardinia: HLA positive and negative associations
Maria Vittoria Masala1, Carlo Carcassi, Francesca Cottoni
1Department of Dermatology, University of Sassari, and Department of Medical Science, University of Cagliari, Italy. fcottoni@uniss.it
Background:
The incidence of classic Kaposi's sarcoma (CKS) in northern Sardinia is one of the highest in the world.
Methods:
Sixty-two patients with CKS were typed for class I and class II antigens. All patients had been born and were living in northern Sardinia.
Results:
In the Sardinian patients, we observed a positive CKS association with Cw7, DRB1*1104, DRB1*1302, DQA1*0302, and DQB1*0604, and a negative CKS association with A30, B58, Cw5, DRB1*1601, and DQB1*0502.
Conclusions:
The strong positive CKS association with DRB1*1104 and DQB1*0604 and negative association with B58 are particularly significant and further support the notion of a genetic predisposition to CKS.
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