Related Experiment Video
Updated: Aug 16, 2026
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
Repetitive transcranial magnetic stimulation in a patient suffering from depression and rheumatoid arthritis:
Berthold Langguth1, Susanne Braun, Josef M Aigner
1Department of Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg, Germany. Berthold.Langguth@medbo.de
Abstract:
Repetitive transcranial magnetic stimulation (rTMS) has been suggested as antidepressive treatment strategy. The mechanism of action by which the antidepressive effect is brought about remains unclear at present. Here, we report findings in a patient suffering from recurrent major depression and rheumatoid arthritis. Improvement of depressive symptoms during 20 Hz rTMS of the left dorsolateral prefrontal cortex was repeatedly associated with a systemic inflammatory reaction, suggesting that rTMS induced an immunomodulatory effect.
