Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lung remodeling in pulmonary tuberculosis.

Keertan Dheda1, Helen Booth, Jim F Huggett

  • 1Centre for Infectious Diseases and International Health, Department of Thoracic and HIV Medicine, Royal Free Hospital, London, United Kingdom. k.dheda@ucl.ac.uk

The Journal of Infectious Diseases
|September 2, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global Tuberculosis Report 2020 - Reflections on the Global TB burden, treatment and prevention efforts.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2021
Same author

Evidences for lipid involvement in SARS-CoV-2 cytopathogenesis.

Cell death & disease·2021
Same author

Addressing challenges to rolling out COVID-19 vaccines in African countries.

The Lancet. Global health·2021
Same author

Zoonotic Tuberculosis - The Changing Landscape.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2021
Same author

Accelerating development of new shorter TB treatment regimens in anticipation of a resurgence of multi-drug resistant TB due to the COVID-19 pandemic.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2021
Same author

Lethal zoonotic coronavirus infections of humans - comparative phylogenetics, epidemiology, transmission, and clinical features of coronavirus disease 2019, The Middle East respiratory syndrome and severe acute respiratory syndrome.

Current opinion in pulmonary medicine·2021

Tuberculosis causes millions of illnesses and deaths globally. Understanding lung remodeling and immune responses in tuberculosis is crucial for developing new treatments to reduce disease spread.

Area of Science:

  • Immunology
  • Pulmonology
  • Infectious Diseases

Background:

  • Tuberculosis (TB) is a major global health crisis, causing millions of illnesses and deaths annually.
  • Pulmonary cavitation in TB facilitates aerosol spread, and lung remodeling leads to significant disability.
  • Efficient granuloma turnover and extracellular matrix remodeling are key to TB resolution without scarring.

Purpose of the Study:

  • To review the pathological mechanisms of lung remodeling in tuberculosis.
  • To examine the immunological pathways involved in tuberculosis immunopathology.
  • To highlight the need for immunotherapeutic interventions targeting immunopathology to reduce TB spread.

Main Methods:

  • Literature review of pathological mechanisms in tuberculosis.

Related Experiment Videos

  • Analysis of immunological pathways in progressive versus resolved tuberculosis.
  • Synthesis of current understanding of lung remodeling in TB.

    • Main Results:

    • Dysregulated granuloma turnover, liquefactive necrosis, and pathological scarring characterize progressive TB.
    • Lung remodeling in TB causes disability exceeding other diffuse parenchymal lung diseases.
    • Understanding these pathological and immunological aspects is essential for TB control.

    Conclusions:

    • Further research into pathological mechanisms and immunological pathways is necessary.
    • Targeting immunopathology with immunotherapies holds potential for reducing TB transmission.
    • Developing specific immunotherapeutic interventions is a critical future direction for TB control.