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Updated: Aug 16, 2026

Estimation of Crystalline Cellulose Content of Plant Biomass using the Updegraff Method
Published on: May 15, 2021
True density of microcrystalline cellulose
1Pfizer Global Research and Development, Portage, Michigan 49001, USA. changquan.sun@pfizer.com
Abstract:
Microcrystalline cellulose (MCC) exhibits unusual tableting properties, sometimes, inconsistent with its high plasticity. It is found that some of the unusual tableting properties of MCC can be explained in part by the use of inaccurate true density during tableting data analysis. MCC true density as a function of water content is determined using a published method that can determine true density of water containing solids. Results suggest that literature MCC true densities tend to be overestimated as a result of limitations in helium pycnometry.
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