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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
1,3-dipolar cycloaddition on solid supports: nitrone approach towards isoxazolidines and isoxazolines and subsequent
Karola Rück-Braun1, Tonia H E Freysoldt, Frank Wierschem
1Technische Universität Berlin, Institut für Chemie, D-10623 Berlin, Germany.
Abstract:
1,3-dipolar cycloaddition reactions of nitrones with alkenes and alkynes are well-studied reactions in solution-phase organic chemistry. However, the number of studies concerned with their application in solid-phase organic synthesis is rather low compared to other 1,3-dipoles, e.g. azides or nitrile oxides. This tutorial review aims to summarise the main approaches towards the application of nitrones in 1,3-dipolar cycloaddition reactions on solid supports in addition to subsequent transformations with polymer-bound isoxazolidines and reactions using polymer-bound catalysts.
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