[Nutritional condition affect the potency of pharmacological therapy]

Recent development of pharmacological treatments with proven efficacy will increase demand for the more effective management of patients with osteoporosis. Osteoporosis is a chronic disease concerned many risk factors such as diet and nutrition, and pharmacological efficacy could much depend on such nutritional conditions in patients as calcium, vitamin D, and protein, etc. Especially Japanese elderly usually took extremely low calcium and protein intake as well as low vitamin D, however, physicians usually give just pharmacological prescription. Therefore firstly we had better assess the nutritional conditions in each patient by body weight, serum albumin, and dietary questionnaires and give them selected pharmacological prescription together with dietary and nutritional guidance for their effective treatment of drugs. Thus we can manage each patient with not only pharmacological but also nutritional treatments that will be effective in cost-performance and good compliance for chronic disease as osteoporosis. Moreover combined nutritional treatments could work more effective in the patients of osteoporosis with inflammatory disease and high nutritional metabolic rate.