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[Do left ventricular mass, diameters and long-axis systolic function differ according to angiotensin converting
Dursun Dursunoğlu1, Halil Tanriverdi, Sebahat Turgut
1Department Of Cardiology, Pamukkale University, Medical Faculty, 20200 Denizli, Turkey. dursundursunoglu@yahoo.com
Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|September 6, 2005
Summary
The ACE DD genotype is linked to higher left ventricular mass (LVM) and mass index (LVMI) in young men, though systolic function remains unaffected. This ACE I/D gene polymorphism impacts cardiac structure.
Area of Science:
- Cardiovascular Genetics
- Molecular Cardiology
- Echocardiography
Background:
- Angiotensin converting enzyme (ACE) plays a crucial role in angiotensin II production, a mediator of myocardial hypertrophy and hyperplasia.
- Understanding the influence of genetic variations, such as ACE I/D gene polymorphism, on cardiac structure and function is vital for cardiovascular health.
- Left ventricular mass (LVM) and dimensions are key indicators of cardiac remodeling and potential cardiovascular risk.
Purpose of the Study:
- To investigate the association between the ACE I/D gene polymorphism and left ventricular mass (LVM), dimensions, and systolic function in healthy young males.
- To determine if specific ACE genotypes correlate with differences in echocardiographic parameters related to cardiac structure and function.
- To assess the relationship between ACE I/D polymorphism and mitral annular motion (MAM)-derived systolic function.
Main Methods:
- Echocardiographic examinations were conducted on 49 healthy male subjects stratified by ACE genotype (DD, DI, II).
- Left ventricular mass (LVM) and mass index (LVMI) were calculated using M-Mode echocardiography.
- Mitral annular motion (MAM) and ejection fraction (EF) were assessed at four sites, with EF also calculated by Simpson's method.
Main Results:
- No significant differences were observed in age, BMI, blood pressure, or heart rate among the ACE genotypes.
- Significant differences in interventricular septum (IVS) and left ventricular posterior wall (LVPW) diastolic thickness, LVM, and LVMI were found.
- LVM and LVMI were higher in the ACE DD genotype group compared to DI and II genotypes, despite all values being within normal limits.
- No significant differences in EF-MAM or EF by Simpson's method were detected among the genotypes.
Conclusions:
- Young healthy males with the ACE DD genotype exhibit higher LVM and LVMI compared to those with ACE DI and II genotypes.
- These structural differences in left ventricular mass are present even when measurements remain within normal physiological ranges.
- The ACE I/D gene polymorphism does not appear to influence left ventricular systolic function as assessed by echocardiography in this cohort.