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Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development
Published on: June 19, 2018
Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans
Oscar Norbeck1, Adiba Isa, Christoph Pöhlmann
1Infectious Diseases Unit, Center of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital L08:03, SE-17177 Stockholm, Sweden. oscar.norbeck@cmm.ki.se
Abstract:
Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8+ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines.
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