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[Multinucleate cells angiohistiocytoma].

S Leclerc1, T Clerici, M Rybojad

  • 1Service d'Anatomie Pathologique, Hôpital Saint-Louis, Paris.

Annales De Dermatologie Et De Venereologie
|September 6, 2005
PubMed
Summary
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Multinucleate cell angiohistiocytoma, a rare vascular proliferation, typically presents as papules on the hands of older women. This report details two atypical cases in a man and a disseminated form, highlighting unusual clinical presentations.

Area of Science:

  • Dermatology
  • Pathology
  • Vascular Biology

Background:

  • Multinucleate cell angiohistiocytoma (MCA) is an uncommon benign vascular proliferation.
  • First described in 1985, MCA typically manifests as small papules on acral sites, predominantly in women over 50.

Observation:

  • This report presents two unusual cases of MCA.
  • Case 1: A 39-year-old man with a two-year history of an arciform papular forehead eruption.
  • Case 2: A 40-year-old woman with a three-year history of a disseminated maculo-papular eruption.

Findings:

  • Histological examination revealed dermal small vessel proliferation with multinucleate cells in both patients.
  • The histological findings confirmed the diagnosis of multinucleate cell angiohistiocytoma.
  • The clinical presentations were atypical for MCA, occurring in a younger male and in a disseminated pattern.

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Implications:

  • These cases expand the known clinical spectrum of multinucleate cell angiohistiocytoma.
  • Highlights the importance of histological confirmation for diagnosis, especially in atypical presentations.
  • Contributes to understanding the rare benign vascular proliferations in dermatology.