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Urticaria and angioedema.

D P Huston1, R B Bressler

  • 1Department of Medicine, Baylor College of Medicine, Houston, Texas.

The Medical Clinics of North America
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

Urticaria and angioedema are mast cell-mediated conditions. This review clarifies their clinical course, histology, and treatment, including antihistamines and corticosteroids, for better understanding and management.

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Area of Science:

  • Dermatology
  • Immunology
  • Pathology

Background:

  • Urticaria and angioedema result from mast cell mediators.
  • Classifying these conditions is challenging due to diverse pathogenesis and clinical courses.
  • Definitions based on duration (acute vs. chronic) lack histological correlation.

Purpose of the Study:

  • To review the clinical course and histology of urticaria and angioedema.
  • To provide a comprehensive understanding of pathogenesis and treatment.
  • To differentiate mast cell-mediated conditions from hereditary angioedema (HAE) and acquired angioedema (AAE).

Main Methods:

  • Review of clinical presentation and histological findings in urticaria and angioedema.
  • Analysis of treatment strategies based on disease severity and underlying mechanisms.

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  • Discussion of specific conditions like physical urticarias, leukocytoclastic vasculitis, and C1 esterase inhibitor deficiency.

    • Main Results:

    • Fleeting lesions show few inflammatory cells; persistent lesions have T cells and monocytes.
    • Leukocytoclastic vasculitis indicates immune complex disease.
    • HAE and AAE mimic mast cell-mediated angioedema but have distinct causes and treatments.

    Conclusions:

    • Histology aids in understanding urticaria and angioedema pathogenesis.
    • Treatment involves antihistamines, corticosteroids, or cytotoxic drugs based on inflammation.
    • Understanding C1 esterase inhibitor deficiency is crucial for diagnosing and managing specific angioedema types.