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Updated: Aug 8, 2026
06:47
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
Published on: September 20, 2011
Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid-phase domains of DMPC lipid
Almut Mecke1, Dong-Kuk Lee, Ayyalusamy Ramamoorthy
1Department of Physics, The University of Michigan, Ann Arbor, Michigan 48109, USA.
Langmuir : the ACS Journal of Surfaces and Colloids
|September 7, 2005
Abstract:
Polycationic polymers are known to disrupt lipid bilayers. In this letter, we report the dependence of this disruption on the lipid structural phase. DMPC bilayers are exposed to two polycationic polymeric nanoparticles, PAMAM dendrimers and MSI-78. We find that regions of the bilayer that are in the gel phase are unaffected by the presence of polymers, whereas the liquid phase is disrupted.
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