Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Mucociliary clearance in childhood].

J Kotzerke1, H von der Hardt, H Wiese

  • 1Abteilung Nuklearmedizin und spezielle Biophysik, Medizinischen Hochschule Hannover.

Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
|April 1, 1992
PubMed
Summary

A novel air-pressure nebulization technique effectively delivers human serum albumin particles for assessing pediatric mucociliary function. This method allows for rapid differentiation between normal and impaired ciliary function in children.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Adults with cystic fibrosis. It's not just about longevity].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2012
Same author

Automatic volume delineation in oncological PET. Evaluation of a dedicated software tool and comparison with manual delineation in clinical data sets.

Nuklearmedizin. Nuclear medicine·2011
Same author

Internal radiotherapy of painful bone metastases.

Methods (San Diego, Calif.)·2011
Same author

Follow-up of FDG-PET/CT findings in retroperitoneal fibrosis associated with abdominal aortic aneurysm.

Nuklearmedizin. Nuclear medicine·2011
Same author

[Nuclear Medicine in Germany. Key data from official statistics].

Nuklearmedizin. Nuclear medicine·2011
Same author

Two or four hour [¹⁸F]FMISO-PET in HNSCC. When is the contrast best?

Nuklearmedizin. Nuclear medicine·2010

Area of Science:

  • Pulmonary medicine
  • Radiopharmacology
  • Particle science

Background:

  • Assessing mucociliary clearance in children is crucial for diagnosing respiratory conditions.
  • Existing methods for mucociliary clearance assessment can be complex and require specialized techniques.
  • Development of simplified, reproducible methods is needed for pediatric lung function evaluation.

Observation:

  • A new, nearly monodisperse human serum albumin particle, generated via air-pressure nebulization, was inhaled by children and lung-transplant patients.
  • Inhalation resulted in marked tracheobronchial deposition without special breathing techniques, with alveolar deposition not exceeding 10%.
  • The use of technetium-99m (99mTc) allowed for low radiation exposure suitable for children, with imaging possible up to 24 hours post-inhalation.

Findings:

Related Experiment Videos

  • Healthy children exhibited a high global clearance rate of 51% within 45 minutes, attributed to particle size and patient age (mean 10.7 years).
  • Patients with ciliary dysfunction showed significantly reduced initial clearance rates of 16% and 46% within 24 hours.
  • The 24-hour retention pattern and particle motion velocity in the trachea served as further in vivo parameters for mucociliary function.

Implications:

  • This simplified air-pressure nebulization method offers a promising tool for evaluating pediatric mucociliary function.
  • The technique's ease of preparation, application, and examination facilitates wider clinical adoption.
  • Rapid differentiation of normal versus impaired ciliary function is achievable due to the fast initial particle elimination.