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[Reference values for IgE concentration in serum of children. Method: ImmunoCAP-FEIA system]

N Liappis1, H Schlebusch, M Niesen

  • 1Zentrum für Kinderheilkunde, Universität Bonn.

Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
|May 1, 1992
PubMed

Insights

This study established age-specific immunoglobulin E (IgE) reference values for children using the ImmunoCAP assay. These values aid in diagnosing elevated IgE levels, crucial for pediatric allergy and immunology assessments.

Area of Science:

  • Pediatric Immunology
  • Allergy Diagnostics

Context:

  • Accurate immunoglobulin E (IgE) reference ranges are essential for diagnosing allergic diseases in children.
  • Existing reference values may not fully capture age-specific variations in IgE levels.

Purpose:

  • To determine age-specific serum IgE reference values in a cohort of 224 children.
  • To provide a reliable basis for identifying pathological elevations of IgE in pediatric populations.

Summary:

  • Serum samples from 224 children were analyzed using the ImmunoCAP fluorescence enzyme immunoassay.
  • Established reference values range from <0.35 kU/L in cord blood to 34.6 kU/L in the 8-12 year age group.
  • Specific ranges were defined for cord blood, and age intervals up to 16 years.

Impact:

  • Facilitates accurate diagnosis of IgE-mediated disorders in children.
  • Supports clinical decision-making in pediatric allergy and immunology.
  • Provides updated, age-stratified reference data for laboratory and clinical use.
Abstract

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