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Related Experiment Videos

Translational crossroads for biomarkers.

Robert C Bast1, Hans Lilja, Nicole Urban

  • 1University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. rbast@mdanderson.org

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|September 8, 2005
PubMed
Summary
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See all related articles

Translating biomarker discovery into clinical cancer care requires collaboration. Key principles include addressing clinical needs and establishing standards for developing useful laboratory tests.

Area of Science:

  • Biomarker discovery and development
  • Translational research in oncology
  • Laboratory test validation

Background:

  • Biomarker discovery is crucial for advancing cancer care, from early detection to treatment monitoring.
  • New markers and technologies offer improved diagnostics for various cancers, including prostate, ovarian, and breast cancer.
  • A clear paradigm for biomarker development is lacking, but key principles are emerging.

Purpose of the Study:

  • To discuss critical issues in translating biomarker discovery into clinical laboratory tests for cancer care.
  • To identify principles and strategies for effective biomarker development.
  • To explore the role of various stakeholders in the biomarker development pipeline.

Main Methods:

  • Discussion at a Specialized Programs of Research Excellence (SPORE) Workshop.

Related Experiment Videos

  • Review of existing examples of biomarker and technology development.
  • Identification of key principles for marker development driven by clinical needs.

    • Main Results:

    • Marker development should prioritize clinical needs such as early detection, staging, and treatment response prediction.
    • A national repository for well-annotated tissue specimens and reference standards are essential.
    • Collaboration between academia, industry, and regulatory bodies like the Food and Drug Administration (FDA) is vital.

    Conclusions:

    • Effective biomarker development necessitates a coordinated approach involving diverse stakeholders.
    • Establishing clear analytical and clinical paradigms is crucial for validating new cancer biomarkers.
    • The National Cancer Institute (NCI) can facilitate collaboration to accelerate biomarker development and application in cancer care.