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[Pulmonary function tests with the bronchodilator Terbutaline].

G Kaik, J Bonelli, G Hitzenberger

    Acta Medica Austriaca. Supplement
    |January 1, 1979
    PubMed
    Summary
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    The beta 2-adrenoceptor agonist terbutaline effectively reduces airway resistance in patients with chronic obstructive airways disease (asthma). Its bronchodilator effects were compared to other medications in clinical trials.

    Area of Science:

    • Pharmacology
    • Respiratory Medicine
    • Clinical Trials

    Background:

    • Chronic obstructive airways disease (COPD) and intrinsic asthma significantly impact lung function.
    • Beta 2-adrenoceptor agonists are a key class of bronchodilators used in managing these conditions.

    Purpose of the Study:

    • To evaluate the acute bronchodilator effect of terbutaline in out-patients with chronic obstructive airways disease (intrinsic asthma).
    • To compare terbutaline's efficacy against other marketed bronchodilators.
    • To assess the cardiovascular effects (heart rate) of terbutaline and other adrenoceptor agonists in healthy volunteers.

    Main Methods:

    • Single-blind, cross-over study design.
    • Airway resistance measured using whole-body plethysmography.

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  • Comparisons included various beta 2-adrenoceptor agonists, vagolytics, and xanthine derivatives.

    • Main Results:

    • Terbutaline demonstrated an acute bronchodilator effect in patients with intrinsic asthma.
    • Comparative data against other bronchodilators were collected.
    • Heart rate effects of terbutaline and other agonists were documented in healthy subjects.

    Conclusions:

    • Terbutaline is an effective bronchodilator for managing intrinsic asthma.
    • The study provides comparative efficacy and safety data for respiratory medications.
    • Further research may explore optimal therapeutic strategies for COPD and asthma.