Is peri-operative cortisol secretion related to post-operative cognitive dysfunction?

L S Rasmussen1, J T O'Brien, J H Silverstein

  • 1Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Summary

Post-operative cognitive dysfunction (POCD) is linked to altered cortisol patterns after surgery. Flattening of the diurnal cortisol rhythm, indicated by reduced morning/afternoon ratios, is significantly associated with POCD development.

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