Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Activated protein C and sepsis.

Lee A O'Brien1, Akanksha Gupta, Brian W Grinnell

  • 1Biotechnology Discovery Research, Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285-0444, USA. bgrinnell@lilly.com

Frontiers in Bioscience : a Journal and Virtual Library
|September 9, 2005
PubMed
Summary

Activated protein C (APC), including drotrecogin alfa, modulates coagulation, inflammation, and apoptosis. It protects the vascular endothelium and prolongs cell and organ survival, particularly in sepsis patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Usefulness of Cytokeratin Fragment Antigen 21-1 Estimation in Fine-Needle Aspiration Washout Specimens in Diagnosis of Axillary Breast Cancer Metastasis.

Journal of cytology·2026
Same author

Target-based Antidiabetic Indole Derivatives and Insights into Structure-activity Relationships: A Mechanistic Update 2020-2025.

Current drug targets·2026
Same author

Association of Vasomotor Symptoms and Cardiac Autonomic Functions in Perimenopausal Women.

Journal of mid-life health·2026
Same author

Defect-Conjugation Coupling in Sulfur and Carbon Co-doped Poly(triazine imide) for Visible-Light-Driven H<sub>2</sub>O<sub>2</sub> Production.

ACS applied materials & interfaces·2026
Same author

Diagnostic utility of EWSR1 in hyalinizing clear cell carcinoma: a systematic review and meta-analysis.

Journal of stomatology, oral and maxillofacial surgery·2026
Same author

Procalcitonin: the bacterial and non-bacterial sepsis marker.

Journal of infection in developing countries·2026

Area of Science:

  • Biochemistry
  • Immunology
  • Vascular Biology

Background:

  • Activated protein C (APC) is a plasma protease crucial for regulating vascular endothelium and innate immunity.
  • Drotrecogin alfa (activated), a recombinant human APC, shows promise in preclinical models and sepsis mortality reduction.

Purpose of the Study:

  • To elucidate the multifunctional mechanisms of APC in modulating coagulation, inflammation, and apoptosis.
  • To investigate how drotrecogin alfa (activated) impacts endothelial dysfunction and leukocyte interactions.

Main Methods:

  • Gene profiling studies.
  • Pharmacological studies.
  • Analysis of endothelial protein C receptor/protease activated receptor-1 mediated mechanisms.

Related Experiment Videos

Main Results:

  • Drotrecogin alfa (activated) directly modulates endothelial dysfunction by inhibiting cytokine signaling, cell adhesion, and vascular permeability, while preventing apoptosis.
  • APC influences leukocyte migration and adhesion via specific receptor-mediated pathways.
  • APC demonstrates anti-inflammatory and pro-survival effects.

Conclusions:

  • APC plays a vital role in the adaptive response at the vessel wall, protecting against vascular insult.
  • APC prolongs endothelial, cellular, and organ survival, especially in the context of sepsis-induced multi-system dysfunction.