Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alcohol intoxication and post-burn complications.

Mashkoor A Choudhry1, Irshad H Chaudry

  • 1Center for Surgical Research, Department of Surgery, University of Alabama, Birmingham, AL 35294, USA. mashkoor.choudhry@ccc.uab.edu

Frontiers in Bioscience : a Journal and Virtual Library
|September 9, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Angiopoietin-2 in Post-Burn Pneumonia.

European burn journal·2026
Same author

Effects of alcohol use on the gut, inflammation, and organ injury: A summary of the 2025 Alcohol and Immunology Research Interest Group (AIRIG) meeting.

Alcohol (Fayetteville, N.Y.)·2025
Same author

Early Dysregulation of Angiopoietin-1 and -2 as a Predictor of Mortality in Critically Ill Burn Patients.

Journal of burn care & research : official publication of the American Burn Association·2025
Same author

Extracellular Cold-Inducible RNA-Binding Protein: Progress from Discovery to Present.

International journal of molecular sciences·2025
Same author

New developments on the effects of alcohol use on immunity, inflammation and organ function: A summary of the 2024 Alcohol and Immunology Research Interest Group (AIRIG) meeting.

Alcohol (Fayetteville, N.Y.)·2025
Same author

Bacterial dysbiosis and decrease in SCFA correlate with intestinal inflammation following alcohol intoxication and burn injury.

eGastroenterology·2025

Alcohol intoxication significantly worsens outcomes for burn injury patients, increasing infection risk and mortality. Monitoring blood alcohol levels in emergency room admissions for burn and trauma patients is crucial for better patient management.

Area of Science:

  • Trauma and Injury Research
  • Public Health
  • Immunology

Background:

  • Alcohol (EtOH) intoxication is a significant public health concern.
  • Few studies have investigated the combined effects of EtOH intoxication and burn injury on host defense.
  • Existing research on the combined insult presents conflicting findings.

Purpose of the Study:

  • To evaluate the impact of acute alcohol intoxication on host defense following burn injury.
  • To analyze clinical and experimental data on the combined effects of alcohol and burn injury.
  • To determine if alcohol intoxication at the time of injury is a risk factor for adverse outcomes.

Main Methods:

  • Analysis of clinical studies on intoxicated burn patients.
  • Review of experimental models examining EtOH intoxication before burn injury.

Related Experiment Videos

  • Laboratory investigations into EtOH's effect on intestinal immunity and gut barrier function.

    • Main Results:

    • Clinical data suggest intoxicated patients have longer hospital stays, delayed healing, and higher mortality.
    • Experimental models show acute EtOH intoxication impairs host defense and increases infection susceptibility.
    • EtOH intoxication before burn injury suppresses intestinal immunity, compromises gut barrier, and increases bacterial translocation and cardiac dysfunction.

    Conclusions:

    • Alcohol intoxication before burn injury diminishes host resistance, increasing susceptibility to infection.
    • Alcohol intoxication at the time of injury is a significant risk factor for infectious complications in burn and trauma patients.
    • Blood alcohol monitoring in emergency room admissions for burn/trauma patients is recommended.